详细描述
姓 名： 谭志杰 (Zhi-Jie Tan)
职务/职称：教 授（博士生导师）
电子邮箱： zjtan@whu.edu.cn
招生专业： 理论物理、凝聚态物理
本课题组欢迎有志于统计物理、软物质物理和生物物理方向的博士生/博士后，特别欢迎他校保研/考研的同学。
Education & Experience：
1996年获武汉大学理学学士，2001年获武汉大学博士学位，期间获中国科学院奖学金，博士学位论文获全国优秀博士论文提名奖和湖北省优秀博士论文。博士生期间留武汉大学任教，2001年破格晋升为副教授，后公派赴美国密苏里大学合作研究，并获得该校生命科学博士后奖学金。2008年6月回到武汉大学，晋升为教授，并被遴选为博士生导师。2008年入选教育部新世纪人才计划，2010年获国家自然科学二等奖（第三完成人），2011年获湖北省青年科技奖。主讲弘毅学堂物理班《热力学与统计物理》和研究生通开课《固体物理II》。目前担任中国物理学会软物质与生物物理专业委员会委员、中国生物信息学会生物大分子结构预测与模拟常委会委员、全国统计物理与复杂系统会议学术委员会委员等，为中国物理学会、美国生物物理学会等学会会员。现主持国家自然科学基金项目，已完成主持国家自然科学基金项目多项。
Research Interests：
1, 发展物理模型，预测RNA、DNA三维结构、热力学及其中离子静电效应;
2, 发展高性能RNA结构评估势能函数和RNA-药物小分子结合势能函数模型;
3, 发展高性能RNA三维结构拼装模型和RNA三维结构优化模型;
4, 利用计算机模拟，预测和理解DNA、RNA结构与力学弹性及其微观机制。
Invited Reviews:
1, Chen et al. A comprehensive evaluation on RNA secondary structures prediction methods. Chin Phys B 34: 088710, 2025.
2, Wang et al. RNA 3D Structure Prediction: Progress and Perspective. Molecules. 28: 5532, 2023.
3, Tan et al. Statistical potentials for 3D structure evaluation: from proteins to RNAs. Chin Phys B 30: 028705, 2021.
4, Bao et al. Flexibility of nucleic acids: from DNA to RNA. Chin Phys B 25: 018703 (1-11), 2016. (2018 CPB high citation article)
5, Tan et al. RNA folding: structure prediction, folding kinetics and ion electrostatics. Adv Expt Med & Biol 827:143-183, 2015.
6, Shi et al. RNA structure prediction: Progress and perspective. Chin Phys B 23: 078701(1-10), 2014.
7, Tan & Chen. Importance of Diffuse Metal Ion Binding to RNA, 9:101-124. in "Structural and Catalytic Roles of Metal Ions in RNA" (volume of Metal Ions in Life Sciences), edited by Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel. 2011.
8, Tan & Chen. Predicting electrostatic forces in RNA folding, 469:465-487, in "Biophysical Approaches to RNA Structure and Folding" (volume of Methods in Enzymology), edited by Daniel Herschlag. 2009.
Selected Articles (as corresponding or 1st author):
1, Lou et al. rsRNASP1: A distance- and dihedral-dependent statistical potential for RNA 3D structure evaluation. Biophys J. 2025 124: 2740-2753, 2025.
2, Dong et al. Effect of protein binding on the twist-stretch coupling of double-stranded RNA. J Chem Phys. 162: 145101, 2025.
3, Dong et al. The origin of different bending stiffness between double-stranded RNA and DNA revealed by magnetic tweezers and simulations. Nucleic Acids Res. 52: 2519-2529, 2024.
4, Zheng et al. Effect of ethanol on the elasticities of double-stranded RNA and DNA revealed by magnetic tweezers and simulations. J Chem Phys. 161: 075101, 2024.
5, Wang et al. Predicting 3D structures and stabilities for complex RNA pseudoknots in ion solutions. Biophys J. 122: 1503-1516, 2023.
6, Tan et al. cgRNASP: coarse-grained statistical potentials with residue separation for RNA structure evaluation. NAR Genom Bioinform. 5: lqad016, 2023.
7, Zhao et al. 5-Methyl-cytosine stabilizes DNA but hinders DNA hybridization revealed by magnetic tweezers and simulations. Nucleic Acids Res. 50: 12344-12354, 2022.
8, Zhou et al. FebRNA: An automated fragment-ensemble-based model for building RNA 3D structures. Biophys J. 121: 3381-3392, 2022.
9, Qiang et al. Multivalent cations reverse the twist-stretch coupling of RNA. Phys Rev Lett 128: 108103, 2022
10, Tan et al. rsRNASP: A residue-separation-based statistical potential for RNA 3D structure evaluation. Biophys J. 121: 142-156, 2022. (New and Notable article)
11, Feng et al. Salt-Dependent RNA pseudoknot stability: effect of spatial confinement. Front Mol Biosci. 8:666369, 2021.
12, Wang et al. An intratumoral injectable nanozyme hydrogel for hypoxia-resistant thermoradiotherapy. Colloids Surf B Biointerfaces. 207: 112026, 2021.
13, Fu et al. Opposite Effects of high-valent cations on the elasticities of DNA and RNA duplexes revealed by magnetic tweezers. Phys Rev Lett 124: 058101, 2020.
14, Wang et al. Salt effect on thermodynamics and kinetics of a single RNA base pair. RNA. 26: 470-480, 2020.
15, Zhang et al. Ion-mediated interactions between like-charged polyelectrolytes with bending flexibility. Sci Rep. 10: 21586, 2020.
16, Jin et al. Structure folding of RNA kissing complexes in salt solutions: predicting 3D structure, stability and folding pathway. RNA. 25: 1532-1548, 2019;
17, Lin et al. Apparent repulsion between equally and oppositely charged spherical polyelectrolytes in symmetrical salt solutions. J Chem Phys 151, 114902, 2019;
18, Liu et al. Structural flexibility of DNA-RNA hybrid duplex: stretching and twist-stretch coupling. Biophys J 117: 74-86, 2019;
19, Tan et al. What is the best reference state for building statistical potentials in RNA 3D structure evaluation? RNA. 25: 793-812, 2019;
20, Jin et al. Modeling structure, stability, and flexibility of double-stranded RNAs in salt solutions. Biophys J 115: 1403-1416, 2018;
21, Shi et al. Predicting 3D structure and stability of RNA pseudoknots in monovalent and divalent ion solutions. PloS Comput Biol 14: e1006222, 2018;
22, Xi et al. Competitive binding of Mg2+ and Na+ ions to nucleic acids: from helices to tertiary structures. Biophys J 114: 1776-1790, 2018;
23, Zhang et al. Potential of mean force between oppositely charged nanoparticles: A comprehensive comparison between Poisson– Boltzmann theory and Monte Carlo simulations. Sci Rep 7: 14145, 2017;
24, Zhang et al. Divalent ion-mediated DNA-DNA interactions: A comparative study of triplex and duplex. Biophys J 113: 517-528, 2017. (Highlighted article);
25, Zhang et al. Radial distribution function of semiflexible oligomers with stretching flexibility. J Chem Phys 147: 054901, 2017. (Featured article);
26, Bao et al. Understanding the relative flexibility of RNA and DNA duplexes: stretching and twist-stretch coupling. Biophys J 112: 1094-1104, 2017;
27, Zhang et al. Potential of mean force between like-charged nanoparticles: many-body effect. Sci Rep 6: 23434 (1-12), 2016;
28, Shi et al. Predicting 3D structure, flexibility and stability of RNA hairpins in monovalent and divalent ion solutions. Biophys J 109: 2654-2665, 2015;
29, Wu et al. Multivalent ion-mediated nucleic acid helix-helix interactions: RNA versus DNA. Nucleic Acids Res 43: 6156-6165, 2015.
30, Wu et al. Flexibility of short DNAs with finite-length effect: from base pairs to tens of base pairs. J Chem Phys 142: 125103(1-13), 2015;
31, Shi et al. A coarse-grained model with implicit salt for RNAs: Predicting 3D structure, stability and salt effect. J Chem Phys 141: 105102(1-13), 2014.
32, Wang et al, Salt contribution to the flexibility of single-stranded nucleic acid of finite length. Biopolymers 99: 370–381, 2013. (Cover story);
33, Tan & Chen. Ion-mediated RNA structural collapse: effect of spatial confinement. Biophys J 103: 827-836, 2012;
34, Tan & Chen. Salt contribution to RNA tertiary structure folding stability. Biophys J 101: 176-187, 2011;
35, Tan & Chen. Predicting ion binding properties for RNA tertiary structures. Biophys J 99: 1565-1576, 2010;
36, Tan & Chen. Salt dependence of nucleic acid hairpin stability. Biophys J 95: 738-752, 2008;
37, Tan & Chen. Electrostatic free energy landscapes for DNA helix bending. Biophys J 94: 3137-3149, 2008;
38, Tan & Chen. RNA helix stability in mixed Na+/Mg2+ solutions. Biophys J 92: 3615-3632, 2007;
39, Tan & Chen. Electrostatic free energy landscapes for nucleic acid helix assembly. Nucleic Acids Res 34:6629-6639, 2006;
40, Tan & Chen. Ion-mediated nucleic acid helix-helix interactions. Biophys J 91: 518-536, 2006;
41, Tan & Chen. Nucleic acid helix stability: effects of salt concentration, cation valency and size, and chain length. Biophys J 90: 1175-1190, 2006;
42, Tan & Chen. Electrostatic correlation and fluctuations for ion binding to finite length polyelectrolyte. J Chem Phys 122:044903(1-16), 2005;
43, Tan et al. Pattern of particle distribution in multi-particle system by random walk with memory enhancement and decay. Phys Rev E 66: 011101, 2002;
44, Tan et al. Deposition, diffusion and aggregation on percolations: A model for nanostructure growth on nonuniform substrates. Phys Rev B 65: 235403, 2002;
45, Tan et al. Pattern formation on nonuniform surfaces by correlated-random sequential adsorption. Phys Rev E 65: 057201, 2002;
46, Tan et al. Random walk with memorial enhancement and decay. Phys Rev E 65: 041101, 2002;
47, Tan et al. Percolation with long-range correlations for epidemic spreading. Phys Rev E 62: 8409-8412, 2000;
48, Tan et al. Structure transition in cluster-cluster aggregation under external fields. Phys Rev E 61: 734-737, 2000;
49, 49, Tan et al. Influence of particle size on diffusion-limited aggregation. Phys Rev E 60: 6202-6205, 1999;
50, Tan et al. Influences of the size and dielectric properties of particles on electrorheological response. Phys Rev E 59: 3177-3181, 1999.
